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目的观察硫辛酸合用甲钴胺治疗糖尿病周围神经病变的临床疗效。方法将120例患者随机分为治疗组60例(硫辛酸0.6/d静脉滴注,甲钴胺1 mg静脉推注1次/d)和对照组60例(灯盏花素40 mg/d静脉滴注,维生素B1100 mg/d、维生素B12500μg/d肌内注射)。结果治疗组肢体疼痛、麻木、发热、发凉、感觉减退的改善率分别为71%、78.7%、58.8%、63.3%、59.4%,均明显高于对照组的35%、43%、23.8%、29.4%、27.8%(P<0.01)有统计学意义,神经传导速度,血液流变学的改善也优于对照组。结论硫辛酸联合甲钴胺治疗糖尿病周围神经病变疗效满意。
Objective To observe the clinical efficacy of thioctic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy. Methods 120 patients were randomly divided into treatment group 60 cases (0.6 mg / L intravenous infusion of lipoic acid, mecobalamin 1 mg intravenous injection once / d) and control group 60 cases (breviscapine 40 mg / d intravenous infusion Note, vitamin B1100 mg / d, vitamin B12500μg / d intramuscular injection). Results The improvement rates of pain, numbness, fever, cold, and sensory loss in the treatment group were 71%, 78.7%, 58.8%, 63.3% and 59.4% respectively, which were significantly higher than those in the control group (35%, 43% and 23.8% , 29.4%, 27.8% respectively (P <0.01). The improvement of nerve conduction velocity and hemorheology was also better than that of the control group. Conclusions Lipoic acid and mecobalamin are effective in treating diabetic peripheral neuropathy.