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应用放射免疫法对８７例甲状腺疾病患者血清进行表皮生长因子（ＥＧＦ）的测定，并与正常对照进行了比较。结果表明：３８例甲亢患者血清ＥＧＦ明显低于正常（Ｐ＜０．０１），其余甲状腺疾病患者血清ＥＧＦ明显高于正常（Ｐ＜０．０５），同时，在甲亢和甲低组中ＥＧＦ与Ｔ＿３、Ｔ＿４含量呈显著的负相关（Ｐ＜０．０１），而在甲状腺肿及甲状腺炎组中ＥＧＦ与Ｔ＿３、Ｔ＿４含量的相关性无显著意义。提示进行血清ＥＧＦ测定对进一步了解甲状腺疾病时甲状腺激素的分泌调节具有重要意义。
Serum EGF was determined by radioimmunoassay in 87 patients with thyroid disease and compared with normal controls. The results showed that the serum EGF of 38 patients with hyperthyroidism was significantly lower than that of normal (P <0.01), and the serum EGF of patients with other thyroid diseases was significantly higher than that of normal (P <0.05) There was a significant negative correlation between the contents of T_3 and T_4 (P <0.01). However, there was no significant correlation between EGF, T_3 and T_4 in goiter and thyroiditis. Tip serum EGF determination of thyroid hormone to further understand the thyroid hormone secretion regulation is of great significance.