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为探讨不同年龄阶段行为偏异儿童血5-羟色胺(5-HT)含量与正常儿童血5-HT含量的差异,寻找其变化规律,为早期干预提供理论依据。应用《Achenbach儿童行为量表》筛查出行为偏异儿童46人,对其中30人检测血5-HT浓度;正常对照组30人。结果,行为偏异组儿童5-HT含量(1.3093±0.8174μmol/L)较正常儿童组(1.1112±0.5673μmol/L)高,但没有显著性差异(t=1.0860、P>0.05),行为偏异儿童不同年龄阶段比较:5-HT含量13～16岁组、6～11岁与4～5岁组比较有显著性差异(t=3.2274,P分别<0.0025、0.001),12～16岁组较6～11岁组高,但没有显著性差异(t=0.6274,P>O.05);与同年龄正常组比较;5-HT含量4～5岁、6～11岁组无显著性差异(t=0.0868、1.0065,P均>0.05),12～16岁行为偏异组5-HT含量显著增高(t=1.7264,P<0.05)。提示:不同年龄阶段行为偏异儿童外周血5-HT含量改变与不同年龄阶段有关,随着年龄增长5-HT浓度渐增高,且与正常儿童差异增大。早期干预效果可能会更好。
To investigate the difference of 5-HT content in children with behavioral deviation at different age stages and normal children’s blood 5-HT content, to find out its variation, provide a theoretical basis for early intervention. A total of 46 children with behavioral deviation were screened using the Achenbach Children’s Behavior Scale. Blood 5-HT levels were measured in 30 of them and 30 in the normal control group. Results Compared with normal children (1.1112 ± 0.5673μmol / L), the 5-HT level in behavioral biased group was significantly higher than that in normal children (t = 1.0860, P> 0.05) Different children at different ages: 5-HT content of 13 to 16 years old group, 6 to 11 years old and 4 to 5 years old group was significantly different (t = 3.2274, P respectively <0.0025,0.001), 12 to 16 years old group (T = 0.6274, P> 0.05). Compared with the same age group, there was no significant difference in the content of 5-HT between 4 and 5 years old and between 6 and 11 years old (t = 0.0868,1.0065, P> 0.05). The content of 5-HT in behavioral biased group was significantly higher at 12-16 years old (t = 1.7264, P <0.05). It is suggested that the change of 5-HT content in peripheral blood of children with behavioral biases at different age stages is related to different age stages. As the age increases, the concentration of 5-HT gradually increases, and the difference with normal children increases. Early intervention may be better.