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细胞色素P45017α酶能够催化孕烯醇酮和黄体酮转化成脱氢表雄酮和雄烯二酮,进而转化为雄激素睾酮和二氢睾酮。这两种雄激素在前列腺癌的发生、发展过程中起了非常重要的作用,体内微量的睾酮和二氢睾酮就能够刺激前列腺癌的增长。因此抑制体内雄激素生物合成的酶即细胞色素P45017α酶则成为对抗前列腺癌的有力武器。本文简要介绍了甾体类细胞色素P45017α酶抑制剂的研究进展。
Cytochrome P45017 alpha enzyme is capable of catalyzing the conversion of pregnenolone and progesterone to dehydroepiandrosterone and androstenedione, which are then converted to androgen testosterone and dihydrotestosterone. Both of these androgens play a very important role in the development and progression of prostate cancer. Trace amounts of testosterone and dihydrotestosterone in the body can stimulate the growth of prostate cancer. Therefore, inhibition of the androgen biosynthesis in vivo enzyme cytochrome P45017α enzyme has become a powerful weapon against prostate cancer. This article briefly introduces the research progress of steroid cytochrome P45017α enzyme inhibitors.