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目的观察羟苯磺酸钙联合单唾液酸四己糖神经节苷脂钠治疗老年糖尿病周围神经病变(DPN)的临床疗效。方法将纳入研究的DPN患者分为试验(A,67例)组和对照(B,64例)组。在控制血糖基础上,A组予单唾液酸四己糖神经节苷脂钠加羟苯磺酸钙治疗,B组予甲钴胺注射液治疗,8周后对两组进行有效性评估。结果(1)治疗8周后,A组密歇根糖尿病神经病变评分量表(MDNS)及密歇根神经病变筛查量表(MNSI)评分较B组及治疗前降低(P均<0.05);(2)治疗8周后,A组冷感觉阈值温度(26.33±1.07)℃较B组(23.17±1.21)℃及治疗前(21.64±1.12)℃升高。A组热感觉、冷痛觉阈值温度分别较B组及治疗前降低(P均<0.05);(3)治疗8周后,A组运动神经传导速度(MCV)中正中神经与腓总神经,以及感觉神经传导速度(SCV)中正中神经与腓总神经均较B组及治疗前升高(P均<0.05)。结论单唾液酸四已糖神经节苷脂钠联合羟苯磺酸钙治疗老年DPN疗效较好。
Objective To observe the clinical efficacy of calcium dobesilate and monosialotetrahexosyl ganglioside sodium in the treatment of senile diabetic peripheral neuropathy (DPN). Methods DPN patients enrolled in the study were divided into experimental (A, 67) and control (B, 64) groups. Based on the control of blood glucose, group A received monosialotetrahexosyl ganglioside plus calcium dobesilate, and group B received mecobalamin. Eight weeks later, the effectiveness of two groups was evaluated. Results (1) After 8 weeks of treatment, the scores of the Michigan Diabetic Neuropathic Disease Scale (MDNS) and the Michigan Neurological Disease Screening Scale (MNSI) in Group A were lower than those in Group B and before treatment (P <0.05) After 8 weeks of treatment, the sensation threshold of cold sensation in group A (26.33 ± 1.07) ℃ was significantly higher than that in group B (23.17 ± 1.21) ℃ and before treatment (21.64 ± 1.12) ℃. (3) After 8 weeks of treatment, the median nerve and common peroneal nerve in motor nerve conduction velocity (MCV) in group A were significantly lower than those in group B and before treatment (P <0.05) The median nerve and common peroneal nerve in sensory nerve conduction velocity (SCV) were higher than those in group B and before treatment (all P <0.05). Conclusion Sodium monosialotetraosyl ganglioside combined with calcium dobesilate treatment of elderly DPN better effect.