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目的 测定单纯疱疹病毒性脑炎 (HSE)患者脑脊液和血清中的S 1 0 0B蛋白和神经元特异性烯醇化酶(NSE)含量 ,并探讨S 1 0 0B蛋白和NSE含量对HSE患者脑损害的评估价值。方法 4 2例HSE患者 (昏迷组 1 6例 ,无昏迷组 2 6例 )和 2 2例正常人对照组脑脊液和血清的S 1 0 0B蛋白和NSE含量 ,均采用酶联免疫吸附试验双抗体夹心法检测 ,并进行动态观察。结果 ①HSE昏迷组的脑脊液和血清S 1 0 0B蛋白和NSE含量显著高于无昏迷组和对照组 (P均小于 0 0 1 ) ,无昏迷组脑脊液S 1 0 0B蛋白和NSE含量与对照组也有差异 (P <0 0 1和 <0 0 1 ) ;②脑脊液S 1 0 0B蛋白和NSE含量随HSE患者病情变化而发生相应的改变 ;③脑脊液S 1 0 0B蛋白和NSE含量分别与其各自的血清含量呈正相关。结论 脑脊液和血清的S 1 0 0B蛋白和NSE可以作为HSE患者脑损害的标志物 ,其含量的高低与胶质细胞和神经元的损害程度有关
Objective To determine the contents of S 1 0 0 B protein and neuron specific enolase (NSE) in cerebrospinal fluid and serum of patients with herpes simplex virus encephalitis (HSE) and to investigate the effect of S 1 0 0 B protein and NSE on brain damage The evaluation value. METHODS: S 1 0 0B protein and NSE content in CSF and serum of 2 HSE patients (16 in coma group and 26 in non-coma group) and 22 healthy controls were measured by enzyme-linked immunosorbent assay Sandwich detection, and dynamic observation. Results ① The contents of S100B protein and NSE in cerebrospinal fluid and serum in HSE coma group were significantly higher than those in non-coma group and control group (P <0.01), and S0 0 0B protein and NSE in non-coma group were also significantly lower than those in control group (P <0.01 and <0.01). (2) S 100B protein and NSE content in cerebrospinal fluid changed correspondingly with the changes of the disease in HSE patients. (3) The contents of S100B protein and NSE in cerebrospinal fluid were correlated with their respective serum Content was positively correlated. Conclusion S100B protein and NSE in cerebrospinal fluid and serum can be used as markers of brain damage in patients with HSE, the level of which is related to the degree of damage of glial cells and neurons