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目的观察急性脑梗死患者病情与其血清脂蛋白相关磷脂酶A2(Lp-PLA2)水平的相关性。方法应用双抗体夹心ELISA法检测急性脑梗死患者(A组,202例)和健康体检者(B组,197例)血清Lp-PLA2水平,分析其与美国国立卫生研究院脑卒中量表神经功能缺损程度评分的相关性。结果 A组血清Lp-PLA2水平高于B组[(178.599±70.579)ng/ml vs.(164.080±54.795)ng/ml](P<0.05)。A组血清Lp-PLA2水平与病情严重程度呈正相关(r=0.238,P<0.01)。结论Lp-PLA2水平的升高与急性脑梗死患者病情严重程度增加密切相关。
Objective To investigate the relationship between the severity of the disease and the level of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with acute cerebral infarction. Methods Serum levels of Lp-PLA2 in patients with acute cerebral infarction (group A, n = 202) and healthy subjects (group B, n = 197) were measured by double antibody sandwich ELISA and compared with those of the National Institutes of Health Stroke Scale Dependency score of the correlation. Results The level of serum Lp-PLA2 in group A was higher than that in group B [(178.599 ± 70.579) ng / ml vs. (164.080 ± 54.795) ng / ml] (P <0.05). Serum Lp-PLA2 level in group A was positively correlated with the severity of disease (r = 0.238, P <0.01). Conclusion The level of Lp-PLA2 is closely related to the severity of acute cerebral infarction.