目的对甘肃省妇女子宫颈人乳头瘤病毒(human papillomavirus,HPV)的感染情况和其高危亚型型别分布进行统计分析,发现其区域性特征,为HPV疫苗的研制及为甘肃省HPV相关研究提供基础数据。方法对2016年7月之前在国内发表的甘肃省HPV感染情况及其亚型分布的10篇研究进行Meta分析。结果甘肃省普通人群组HPV总感染率为26.82%,CIN组总HPV感染率为60.24%,浸润癌(ICC)组总HPV感染率为88.79%,宫颈癌患者前6位高危型别依次为HPV-16、HPV-58、HPV-18、HPV-52、HPV-33和HPV-31型,累计阳性率高达92.00%。结论甘肃省HPV感染率高,迫切需要HPV疫苗;甘肃省的优势型别为HPV-16、HPV-58、HPV-18、HPV-52、HPV-33和HPV-31型,区域性预防性疫苗应纳入当地优势型别。 Objective To investigate the prevalence and prevalence of human papillomavirus (HPV) in women in Gansu Province and to find out the regional characteristics of HPV infection. To develop HPV vaccine and to study HPV in Gansu Province Provide basic data. Methods Meta-analysis was performed on 10 studies of HPV infection and its subtype distribution in Gansu Province before July 2016. Results The total HPV infection rate was 26.82% in the general population of Gansu Province, 60.24% in CIN group, 88.79% in invasive carcinoma (ICC) group, and the top 6 cases of cervical cancer were The positive rate of HPV-16, HPV-58, HPV-18, HPV-52, HPV-33 and HPV-31 was 92.00% Conclusion The HPV infection rate is very high in Gansu province and the HPV vaccine is urgently needed. The predominant genotypes in Gansu Province are HPV-16, HPV-58, HPV-18, HPV-52, HPV-33 and HPV- Should be included in the local dominance type.