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目的 探讨nm 2 3 -H 1和CD 44V 6蛋白在胃癌组织中的表达及其与临床病理特征的关系。方法 应用免疫组织化学方法 ,检测 95例胃癌组织中nm 2 3 -H 1和CD44V 6蛋白的表达情况。结果 nm 2 3 -H 1和CD 44V 6蛋白阳性表达率分别为5 4.7%、75 .8%。CD44V 6蛋白表达与癌细胞分化程度显著相关 (P <0 .0 1) ,nm 2 3 -H 1和CD 44V 6的表达与其它临床病理特征无明显相关性 (P >0 .0 5 )。结论 nm 2 3 -H 1和CD44V 6蛋白在胃癌发生发展中起着重要作用 ,CD44V 6表达与癌细胞分化程度密切相关
Objective To investigate the expression of nm 2 3 -H 1 and CD 44V 6 in gastric carcinoma and its relationship with clinicopathological features. Methods Immunohistochemistry was used to detect the expression of nm 2 3 -H 1 and CD44V 6 in 95 cases of gastric cancer. Results The positive expression rates of nm 2 3 -H 1 and CD 44V 6 protein were 57.4% and 75.8% respectively. There was a significant correlation between the expression of CD44V6 protein and the degree of cancer cell differentiation (P <0.01). The expressions of nm23-H1 and CD44V6 had no significant correlation with other clinicopathological features (P> 0.05). Conclusion The nm 2 3 -H 1 and CD44V 6 proteins play an important role in the development of gastric cancer. The expression of CD44V 6 is closely related to the differentiation of cancer cells