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1目的探讨糖尿病性视网膜病变(diabetic retinopathy DR)的发病危险因素及其与血清配体CXC趋化因子配体16(CXC chemokine ligand16,CXCLl6)的关系。2方法按照1999年WHO糖尿病诊断标准,选取86例于我院内分泌科住院的2型糖尿病(T2DM)患者作为研究对象,其中伴有DR者作为观察组(DR组);单纯糖尿病者作为对照组(DM组)。所有受试者均测定CXCLl6、糖化血红蛋白(Hemoglobin A1c,HbA1c)及其他相关生化指标,并进行葡萄糖耐量试验(Oral Glucose Tolerance Test,OGTT)及胰岛素释放试验。此外测量全部受试者的身高、体质量、腰围、臀围以及血压。对两组患者血清CXCL16水平的差异及其与DR之间的关系进行分析。采用SPSS 17.0统计软件对数据进行分析处理。3结果 DR组的胰岛素抵抗指数(HMA-IR)、HbAlc、C反应蛋白(CRP)、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇以及CXCL16水平明显高于DM组,差异有统计学意义,说明这些指标可能是DR的影响因素;血清CXCL16≥1.22μg/L的糖尿病患者发生DR的危险性是CXCL16<1.22μg/L的3.27倍;CXCL16是发生DR的主要危险因素。4结论 CXCL16是DR发生的危险因素之一。
1 Objective To investigate the risk factors of diabetic retinopathy (DR) and its relationship with serum CXC chemokine ligand 16 (CXCLl6). Methods According to the WHO diagnostic criteria of WHO in 1999, 86 type 2 diabetes mellitus (T2DM) patients admitted to Department of Endocrinology of our hospital were selected as subjects, with DR as observation group (DR group) and simple diabetes as control group (DM group). All subjects tested CXCL16, Hemoglobin A1c (HbA1c) and other related biochemical parameters, and performed Oral Glucose Tolerance Test (OGTT) and insulin release test. In addition, the height, body mass, waist circumference, hip circumference, and blood pressure of all subjects were measured. The differences of serum CXCL16 levels between the two groups and their relationship with DR were analyzed. SPSS 17.0 statistical software was used to analyze the data. 3 Results The levels of HMA-IR, HbAlc, C-reactive protein (CRP), fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol and CXCL16 in DR group were significantly higher than those in DM group Significance, indicating that these indicators may be the impact of DR factors; serum CXCL16 ≥ 1.22μg / L in patients with diabetes risk of CXCL16 <1.22μg / L 3.27 times; CXCL16 is the main risk factor for the occurrence of DR. 4 Conclusion CXCL16 is one of the risk factors for DR.