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抗毒蕈碱化合物哌仑西平(pirenzepine)是胃壁细胞 M_1受体的特异性抑制物,其治疗剂量使基础及五肽胃泌素刺激的酸排量分别减少74%及22%。文献报道临床试验对十二指肠溃疡的治愈率为62～86%。有资料表明,夜间小剂量哌仑西平50mg 夜间服抑制
The antimuscarinic compound pirenzepine is a specific inhibitor of M 1 receptor in gastric parietal cells and its therapeutic dose decreases basal and pentagastrin-stimulated acid secretion by 74% and 22%, respectively. Reported in the clinical trials of duodenal ulcer cure rate was 62 ~ 86%. Data show that nighttime low dose pirenzepine 50mg night service inhibition