The microtubule-associated protein tau was identified in the neurofibrillary tangles (NFTs) of Alzheimer's disease (AD) more than 30 years ago, and its mutation
Dr.Leslie Ungerleider, who together with Mortimer Mishkin established the model of “two functionally dissociated cortical visual pathways in the primate brain
Dissecting inter-regional connectivity at the cellular level is a key step towards understanding the functional oper-ation scheme of a complex brain network.Lar
With the development of in vivo imaging techniques, it was discovered early in this century that microglia are highly dynamic even in the resting state [1].Howe
Parkinson disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopamine neurons in the substantia nigra, resulting in striatal d
The locus coeruleus(LC)is one of the essential chemoregulatory and sleep-wake(S-W)modulating cen-ters in the brain.LC neurons remain highly active during wakefu
Neuroinflammation and α-synuclein(α-syn)aggregation are both neuropathological hallmarks of Parkinson's dis-ease(PD).Microglia are crucial participants in eli
Huntington's disease(HD)is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion exceeding a threshold length(>35 repea
Stroke is a leading disease for morbidity and the second leading cause of mortality following ischemic heart disease.The health burden for stroke ranks the four