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临床造血干细胞移植(HCT)技术已广泛应用,其中存在一个关键性待解决的问题:ABO血型不合的造血干细胞移植引起的免疫性溶血。正常情况异体HCT患者应该接受ABO血型相同供体的干细胞。但人类白细胞抗原(HLA)和ABO血型基因分别位于不同的染色体,寻找HLA与ABO血型均相合的供体比较困
Clinical hematopoietic stem cell transplantation (HCT) technology has been widely used, and there is a key problem to be solved: immune hemolysis caused by ABO incompatible hematopoietic stem cell transplantation. Normal patients with allogenic HCT should receive stem cells of the same donor as the ABO blood group. However, human leukocyte antigen (HLA) and ABO blood group genes are located in different chromosomes, looking for HLA and ABO blood type are more complicated donor comparison