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目的 :研究在正常小型猪主动脉置入自膨式血管内支架 (ES)后再狭窄形成的机制及行经皮血管成形术 (PTA)的可行性。材料和方法 :中华小型猪 7只。 1只为预实验组 ,行血管造影后处死。 6只为实验组并随机分为 3组 ,均于主动脉弓降部置入血管内支架。组 1和组 2、3分别于术后 3个月及 3、6个月行血管造影 ;其中组 3术后 6个月对狭窄行经皮血管成形术。结果 :血管内支架均成功置入实验组主动脉弓降部。术后 6个月生长发育所致平均狭窄百分面积为 6 .6 0± 3 .5 5 %,内膜增殖所致平均狭窄百分面积为 1 4.6 1± 0 .3 7%。术后第 6个月血管内支架置入处前后收缩期压差为 1 .76± 0 .3 7kPa ,行球囊扩张术后压差消失。结论 :自膨式血管内支架置入小型动物主动脉可因其生长发育造成再狭窄 ,并随时间推移加重。行经皮血管成形术疗效满意
Objective: To investigate the mechanism of restenosis and the feasibility of percutaneous transluminal angioplasty (PTA) in aorta of miniature porcine aorta after implantation of self-expandable stent. Materials and Methods: 7 Chinese miniature pigs. 1 pre-experimental group, angiography after sacrifice. Six experimental groups were randomly divided into three groups, all in the aortic arch into the endovascular stents. Group 1 and group 2 and group 3 underwent angiography at 3 months and 3 and 6 months after operation, respectively. Group 3 received stenosis at 6 months after operation for percutaneous transluminal angioplasty. Results: Endovascular stents were successfully placed in the descending aorta of the experimental group. The average percentage of stenosis caused by growth and development at 6 months after operation was 6.60 ± 3.55%, and the average percentage of stenosis caused by intimal proliferation was 1 4.6 1 ± 0.37%. The pressure difference before and after stent implantation at 6 months after operation was 1.76 ± 0.37kPa, and the pressure drop disappeared after balloon dilation. CONCLUSIONS: Self-expanding intravascular stents implanted into the aorta of small animals can cause restenosis due to their growth and development, and aggravate with time. Percutaneous transluminal angioplasty was effective