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目的:探讨血锂浓度≥1.0mmol/L的慢性锂中毒患者血锂浓度、中毒症状与治疗之间的关系。方法:查阅150例血锂浓度≥1.0mmol/L的慢性锂中毒患者的病历记录,采集人口学资料及临床特征。结果:高剂量、高龄、女性、合并苯二氮艹卓类药物者血锂浓度较高。中毒症状与血锂浓度密切相关,血锂浓度越高,越容易中毒。血液透析对锂的排除率高于常规治疗。结论:长期服用锂盐的患者应监测血锂浓度,警惕危险因素,临床医生需密切观察中毒症状。
Objective: To investigate the relationship between blood lithium concentration, poisoning symptoms and treatment in chronic lithium poisoning patients with blood lithium concentration ≥1.0mmol / L. Methods: The records of 150 chronic lithium poisoning patients with blood lithium concentration ≥1.0mmol / L were recorded and the demographic data and clinical features were collected. Results: High dose, elderly, female, benzodiazepine drugs with high blood lithium concentration. Poisoning symptoms and blood lithium concentration is closely related to the higher blood lithium concentration, the more easily poisoned. Hemodialysis on lithium exclusion rate higher than conventional treatment. Conclusion: Patients taking lithium for a long time should monitor blood lithium concentration and be alert to risk factors. Clinicians should observe the symptoms of poisoning closely.