本研究观察离体状态下一氧化氮前体L—精氨酸及一氧化氮合成抑制剂N~G—硝基—L—精氨酸甲酯对犬十二指肠运动功能的影响。结果表明L—精氨酸能明显抑制十二指肠的收缩,而N~G—硝基—L—精氨酸甲酯能抵销其抑制作用。结果支持一氧化氮作为非肾上腺素能非胆硷能神经的主要介质,参与十二指肠运动功能的调节,表现为运动抑制。 This study was designed to observe the effects of L-arginine, a nitric oxide precursor, and N-G-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, on the duodenum motility in dogs. The results show that L-arginine can significantly inhibit the contraction of the duodenum, while N ~ G-nitro-L-arginine methyl ester can offset its inhibition. The results support nitric oxide as the main mediator of non-adrenergic non-cholinergic nerve involved in the regulation of duodenal motor function, manifested as motor inhibition.