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目的探讨糖尿病人群性别差异与新发脑梗死事件的相关性。方法采用前瞻性队列研究方法,以空腹血糖≥7.0 mmol/L或<7.0 mmol/L但已确诊为糖尿病、正在使用降糖药物的8 306例糖尿病人群作为观察队列,随访(48.01±3.14)个月,随访期间每半年收集一次新发脑梗死事件情况。分析糖尿病人群性别差异与新发脑梗死事件的相关性。结果(1)与女性组相比,男性组收缩压、舒张压水平较高,空腹血糖、HDL-C水平较低,差异有统计学意义(P<0.05)。(2)男性组累积发生脑梗死事件率高于女性组(2.9%对2.0%),差异有统计学意义(P<0.05)。校正年龄、性别、BMI、SBP、DBP、FPG、TC、TG、LDL-C、HDL-C及吸烟因素,Cox比例风险回归分析表明,男性组发生脑梗死事件的相对危险(RR)为女性组的1.58倍(95%CI:1.05~2.38,P<0.05)。结论男性是糖尿病人群脑梗死事件的独立危险因素。
Objective To investigate the relationship between gender differences in diabetes and new-onset cerebral infarction. Methods A prospective cohort study was conducted in a cohort of 8 306 diabetics with hypoglycaemia ≥7.0 mmol / L or <7.0 mmol / L, who were diagnosed with diabetes and were using hypoglycemic agents. Follow-up was (48.01 ± 3.14) years Month, during the follow-up period every six months to collect new cases of cerebral infarction. To analyze the correlation between gender differences in diabetes and new-onset cerebral infarction. Results (1) Compared with female group, male patients had higher systolic blood pressure, higher diastolic blood pressure and lower fasting blood glucose and HDL-C, with statistical significance (P <0.05). (2) The cumulative incidence of cerebral infarction in male group was higher than that in female group (2.9% vs 2.0%), the difference was statistically significant (P <0.05). Cox proportional hazards regression analysis showed that the relative risk (RR) of male patients with cerebral infarction was adjusted to be female in age group, sex, BMI, SBP, DBP, FPG, TC, TG, LDL-C, HDL- 1.58-fold (95% CI: 1.05-2.38, P <0.05). Conclusion Male is an independent risk factor for cerebral infarction in diabetic population.