Gastrointestinal stromal tumor (GIST) represents the most common intramural mesenchymal tumor of the gastrointestinal tract,but the synchronous occurrence of GIST in the stomach and gynecological cancer is rare.We present a unique case of a 56-year-old female patient who was diagnosed with the synchronous development of GIST and an isolated parenchymal splenic metastasis of ovarian cancer.She underwent a wide local excision of gastric lesions with splenectomy.A morphological (histological and immunohistochemical) study established a spindle-cell type of gastrointestinal tumor that expressed CD117,and a parenchymal recurrence of ovarian papillary serous adenocarcinoma.The patient has remained alive and disease-free for 30 months since the last operation.A small GIST concomitant with an isolated parenchymal splenic metastasis of ovarian cancer is rarely encountered.The coexistence of GIST with other malignancies constitutes an intriguing oncologic model.Surgeons are advised to be alert against possible primary GIST accompanying other neoplasms.