由于缺乏生长因子,慢性伤口患者进行反复清创却鲜有成效.富血小板血浆(Platelet-rich plasma,PRP)已被证明通过多种生长因子促进组织愈合.评估了17例患者接受自体PRP治疗下肢慢性创伤的临床疗效.为了促进伤口愈合和控制感染,两次治疗间隔2个月.研究发现PRP治疗后慢性伤口的平均体积明显减少.此外,17例患者中有10例伤口完全愈合,其中有6例出现骨不连再愈合现象,另有6例伤口愈合率超过50％.PRP治疗也使创面内渗出物细菌培养的阳性率从82.4％下降到11.8％.因此,本研究表明PRP治疗能够有效促进慢性创面愈合,是治疗某些复杂慢性创面的有效方法.“,”Patients with chronic wounds frequently undergo repetitive debridement without a definitive outcome because of the scarcity of growth factors.Platelet-rich plasma(PRP)has been shown to enhance tissue healing with multiple growth factors.We evaluated the clinical effects of PRP in the treatment of chronic wounds.Seventeen patients with chronic wounds on the lower limbs were treated with the application of autologous PRP twice at a 2-month interval to close the wound and control infection.We found that the average vol-ume of the chronic wounds significantly decreased.In addition,10 of the 17 patients had complete wound coverage and another 6 patients had >50％ wound coverage.Fracture re-union was also observed in 6 of the 10 patients with complete wound coverage.PRP treat-ment also dramatically reduced the positive results of bacterial culture,from 82.4％ to 11.8％.Therefore,we concluded that PRP treatment can efficiently facilitate chronic wound healing and be considered an effective treatment during the management of some complicat-ed chronic wounds.