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本研究对４９例不同组织类型的肛管癌从ｐ５３蛋白表达的改变和细胞形态定量分析的角度探讨该肿瘤的发生机理及ｐ５３蛋白免疫组化的临床意义。研究结果：（１）６１２％的肛管癌有ｐ５３的过度表达，说明ｐ５３表达改变是肛管癌的一个常见现象；（２）免疫组化结果积分与ＤＮＡ含量改变有相关性。３分以上组与小于等于３分组ＤＮＡ指数均值有统计学差异，表明两组生物学行为可能不同，故ｐ５３积分可作为估计病人预后的又一个辅助指标；（３）在某些良性病变的鳞状上皮中也检测到有ｐ５３表达，表明ｐ５３免疫组化不能作为区别良恶性的指标。
This study investigated the pathogenesis of the tumor and the clinical significance of p53 protein immunohistochemistry in 49 cases of different types of anal canal cancer from the perspective of p53 protein expression and quantitative analysis of cell morphology. Results: (1) 61. 2% of anal canal cancers have p53 overexpression, indicating that p53 expression is a common phenomenon of anal canal cancer; (2) There is a correlation between the scores of immunohistochemistry and DNA content changes. There was a statistically significant difference in the mean score of the subgroups with 3 or more points and less than or equal to 3, indicating that the biological behaviors of the two groups may be different. Therefore, the p53 score can be used as another auxiliary index to estimate the prognosis of the patients; (3) The scale of certain benign lesions Expression of p53 was also detected in the epithelium, indicating that p53 immunohistochemistry cannot be used as an indicator of distinguishing benign from malignancy.