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合成了14个具有复合功能的三脚架型多苯并咪唑季铵盐类化合物3a~3n,并对其进行了结构表征.探究了目标化合物3对Cdc25B和PTP1B的抑制活性,结果发现,目标产物3d、3e、3i、3j和3l对Cdc25B表现出优良的抑制活性,其中3d、3e、3j和3l的IC50值低于参照物钒酸钠,有望成为用于治疗癌症的潜在的Cdc25B抑制剂;3d、3e、3i和3l对PTP1B表现出良好的抑制活性,3l的IC50值低于参照物齐墩果酸,有望作为用于治糖尿病潜在的PTP1B抑制剂.研究了生命体系中重要的6种不同阴离子对4个代表性目标化合物的荧光猝灭,结果发现,I-对目标化合物表现出了优良的猝灭效果,其中对3c和3e猝灭作用最为明显,有望成为一种潜在的I-荧光识别探针.
Fourteen complex-functionalized triphenylbenzimidazole quaternary ammonium compounds 3a ~ 3n were synthesized and their structures were characterized.The inhibitory activity of target compound 3 on Cdc25B and PTP1B was explored, and it was found that the target product 3d , 3e, 3i, 3j and 3l showed good inhibitory activity on Cdc25B. The IC50 values of 3d, 3e, 3j and 3l were lower than the reference sodium vanadate, which is expected to be a potential Cdc25B inhibitor for cancer treatment. , 3e, 3i and 3l showed good inhibitory activity on PTP1B, and the IC50 value of 3l was lower than the reference oleanolic acid, which is expected to be a potential PTP1B inhibitor for treating diabetes. The results showed that I- showed excellent quenching effect on the target compounds, of which the quenching effect on 3c and 3e was the most obvious, which is expected to become a potential I-fluorescence Identify the probe.