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目的 探讨帕金森病患者轻度认知功能障碍(mild cognitive impairment in Parkinson’s disease,PD-MCI)与血清同型半胱氨酸(Hcy)水平的相关性.方法 本研究纳入85名PD患者,将其分为PD-MCI组(n=43)和帕金森病认知功能正常组(PDN组,n=42),另选取43名健康老年人为对照组(HC组).所有受试者完成人口统计学的信息、临床和神经心理学评估以及空腹静脉血Hcy水平检测,同时在PD-MCI组进行Hcy水平与其相关因素的分析.结果 PD患者血清Hcy水平[(13.53±2.29) μmol/L]高于HC组[(11.77±1.56) μmol/L],差异有统计学意义(t=4.57,P＜0.05).HC组、PDN组[(12.85±1.88) μmol/L]和PD-MCI组[(14.22±2.47) μmol/L]血清Hcy水平比较差异有统计学意义(F=16.13,P=0.001);进一步两两比较,PDN组高于HC组,差异有统计学意义(P＜0.05);PD-MCI组高于PDN组,差异有统计学意义(P＜0.05).PD-MCI患者血清Hcy水平与UPDRS-Ⅲ评分(r=0.305)、H-Y分级(r=0.313)、LEDD用量(r=0.424)、MMSE(r=-0.470)、MoCA(r=-0.503)、连线测试B耗时数(r=0.617)以及词义流畅性测试(r=0.557)呈显著相关(均P＜0.05).结论 血清Hcy水平有望成为预测PD-MCI的生物标记物.“,”Objective To investigate the correlation between mild cognitive impairment (PD-MCI) and serum homocysteine (Hcy) in patients with Parkinson’s disease.Methods 85 patients with PD (43 with PD-MCI,42 with PDN) as the observation group and 43 healthy elderly patients as the control group.The demographic information,clinical and neuropsychological assessments were conducted and the Hcy of fasting venous blood were detected in all subjects.The I-Icy level and its associated factors were also analyzed in the PD group.Results Serum levels of Hcy in the PD patients((13.53±2.29) μmol/L) were higher than those in the HC group((11.77±1.56) μmol/L),the difference was statistically significant (t=4.57,P ＜0.05).There was significant difference in serum Hcy levels among HC group,PDN group ((12.85 ± 1.88) μmoL/L) and PD-MCI group((14.22±2.47) ±mol/L) (F=16.13,P＜0.01).Hcy level of the PDN group was higher than that of the HC group (P＜0.05),and PD-MCI group was higher than PDN group (P＜0.05).Serum levels of Hcy in patients with PD-MCI were significantly associated with UPDRS-Ⅲ (r=0.305),H-Y (r=0.313),LEDD (r=0.424),MMSE (r =-0.470),MoCA (r=-0.503),duration of connection test B (r =0.617) and semantic fluency tests (r=0.557) (all P＜0.05).Conclusion Elevated serum Hcy levels are expected to be biomarkers for predicting PD-MCI.