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目的从细胞增殖活性方面的变化探索胃粘液癌预后较差的原因。方法用免疫组化ＡＢＣ方法原位检测胃粘液癌组织中癌细胞增殖细胞核抗原（ｐｒｏｌｉｆｅｒａｔｉｎｇｃｅｌｎｕｃｌｅａｓａｎｔｉｇｅｎ，ＰＣＮＡ）的表达，推测癌组织中的增殖情况。结果粘液腺癌ＰＣＮＡ阳性表达指数（ＰＩ）为３８．３３±２２．３９，ＰＩ＞２０的比例为８３．３％；粘液细胞癌前期的单核细胞样癌细胞ＰＩ为４２．２２±２４．９６，ＰＩ＞２０比例为８８．９％，后期的印戒样癌细胞ＰＩ为１．００±１．２７，无一例ＰＩ超过２０，粘液腺癌和单核细胞样癌细胞之间ＰＩ差别无显著性（Ｐ＞０．０５），粘液细胞癌的前期单核细胞样癌细胞与后期印戒样癌细胞之间，ＰＩ的差异有显著性（Ｐ＜０．０１）。结论粘液细胞癌的增殖活性主要看其前期的单核细胞样癌细胞，胃粘液癌细胞增殖活性较高是其恶性程度较高的部分原因。
Objective To explore the causes of poor prognosis of gastric mucinous carcinoma from the changes in cell proliferation activity. Methods Immunohistochemical ABC method was used to detect the expression of proliferating cell nuclear antigen (PCNA) in gastric mucinous tissues in situ, and the proliferation in cancer tissues was inferred. Results The positive expression index (PI) of PCNA in mucinous adenocarcinoma was 38.33±22.39, the ratio of PI>20 was 83.3%, and the PI of precancerous mucinous cell carcinoma was 42.22±24. 96, PI>20 ratio was 88.9%, PI of late signet ring cancer cells was 1.00±1.27, no PI was more than 20, PI difference between mucinous adenocarcinoma and monocyte-like cancer cells was not Significantly (P>0.05), there was a significant difference in PI between early monocyte-like cancer cells and posterior signet ring cancer cells in mucinous cell carcinoma (P<0.01). Conclusion The proliferative activity of mucinous cell carcinoma mainly depends on its previous monocyte-like carcinoma cells. The high proliferation activity of gastric mucinous carcinoma cells is partly responsible for its higher malignancy.