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目的观察多西他赛联合替吉奥治疗老年性晚期胃癌的疗效及安全性。方法用多西他赛60 mg·m-2,第1 d;替吉奥60 mg·m-2,分2次餐后口服,第1～14 d。21 d为1个周期,至少进行2个周期。结果 35例患者中,完全缓解4例,部分缓解18例,无变化7例,疾病进展6例,总有效率为62.86%。中位肿瘤进展时间7个月,中位生存时间9个月。最常见不良反应为骨髓抑制、脱发、胃肠道反应、周围神经毒性;胃穿孔2例,无化疗相关性死亡。结论多西他赛联合替吉奥治疗老年性晚期胃癌具有较好疗效,毒副作用可以耐受。
Objective To observe the efficacy and safety of docetaxel and tegaserod in the treatment of senile advanced gastric cancer. Methods Docetaxel 60 mg · m-2 on the first day; for the geo-60 mg · m-2, two times after oral administration, the first ~ 14 d. 21 d for a period of at least 2 cycles. Results Of the 35 patients, 4 were completely relieved, 18 were partially relieved, 7 were unchanged, 6 were disease progression, with a total effective rate of 62.86%. The median tumor progression time of 7 months, the median survival time of 9 months. The most common adverse reactions were myelosuppression, alopecia, gastrointestinal reactions, peripheral neurotoxicity; gastric perforation in 2 cases, no chemotherapy-related deaths. Conclusion Docetaxel combined with tigiao for the treatment of elderly patients with advanced gastric cancer has a good effect, toxic side effects can be tolerated.