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用转录因子诱导的多功能干细胞(induced pluripotentstem cell,iPS)应用于临床治疗病人目前有三个障碍:一是诱导效率极低,二是致肿瘤性,三是iPS的定向分化。最近,Szabo等可以将人成纤维细胞直接转化成多种血液细胞,无需经过多能干细胞阶段。他们在人成纤维细胞中高表达转录因子
Inducible pluripotent stem cells (iPS) induced by transcription factor are currently used in clinical treatment of patients with three obstacles: one is very low induction efficiency, the other is tumorigenicity; the other is directional differentiation of iPS. Recently, Szabo et al. Have been able to directly transform human fibroblasts into a variety of blood cells without passing through the pluripotent stem cell stage. They highly express transcription factors in human fibroblasts