梗阻性黄疸病人血循环中有内毒素者术后发生急性肾功能衰竭达9％。内毒素血症被认为是肠道吸收内毒素增加并进入门静脉,而肝内纲状上皮系统的清除作用降低所致。术前口服胆盐、去氧胆酸钠和牛磺胆酸钠可防止内毒素血症并保护病人术后的肾功能。但在英国市场上可买到的用于溶解胆石的胆盐如熊去氧胆酸和鹅去氧胆酸对人无效。乳果糖,一种无毒、合成的二糖(半乳糖苷果糖)。常用于治疗便秘和预防肝性脑病。一些研究显示口服此药可防治内毒素血症,但其对梗阻性黄疽的作用尚 Obstructive jaundice patients with endotoxin in the blood circulation after acute renal failure occurred up to 9%. Endotoxemia is thought to be due to an increase in endotoxin uptake into the portal vein and a decrease in the clearance of the intrahepatic metaphase epithelium. Preoperative oral bile salts, sodium deoxycholate and sodium taurocholate prevent endotoxemia and protect the patient’s renal function. However, bile salts such as ursodeoxycholic acid and chenodeoxycholic acid which are available on the market in the United Kingdom for dissolving gallstones are ineffective. Lactulose, a non-toxic, synthetic disaccharide (galactosyl fructose). Commonly used in the treatment of constipation and prevent hepatic encephalopathy. Some studies have shown that oral administration of this drug can prevent endotoxemia, but its effect on obstructive jaundice