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1960年,Nowell 和 Hungerford 在慢性粒细胞白血病(CML)病人的骨髓细胞中,首先发现 Ph~1染色体。随着细胞遗传学和分子遗传学技术的发展,对 CML 的认识愈来愈深入;不但确定了传统的 Ph~1是 t(9;22)(q~(34.1);q~(11.2))的结果,而且 DNA 分子杂交技术还证明了,位于9q~(34)的原癌基因 c-abl,在 Ph~1易位中恒定受累,并在 CML 的发生学上越着重要作用。这样,更激起了人们对是否所有 CML病侧都存在 Ph~1染色体的问题产生了浓厚的兴趣。本文就近几年来有关 CML 中 Ph~1 的一些进展作一简要综述。
In 1960, Nowell and Hungerford first found Ph ~ 1 chromosomes in bone marrow cells of patients with chronic myeloid leukemia (CML). With the development of cytogenetics and molecular genetics, the understanding of CML has been further deepened. Not only the traditional Ph ~ 1 was identified as t (9; 22) (q ~ (34.1); q ~ (11.2)) DNA hybridization has also demonstrated that c-abl, a proto-oncogene located at 9q ~ (34), is constitutively involved in Ph ~ 1 translocation and plays an important role in the genesis of CML. In this way, people are even more excited about the existence of Ph ~ 1 chromosomes on all diseased CML has a strong interest. In this paper, we summarize some progress of Ph ~ 1 in CML in recent years.