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顺氯氨铂简称氯氨铂或顺—铂,全名顺—二氯二氨铂[cis-Dichlorodiammineplatinum(11)],简称DDP。1965年 Rosenberg 发现它的抗癌性能,对此药物已进行了许多研究,国内也已有生产。现已证明它是一种新的广谱抗癌药物,不但对骨肉瘤及软组织肉瘤有效,而且对头与颈部肿瘤、小细胞性肺癌、妇科恶性肿瘤、前列腺和膀胱癌、睾丸肿瘤幅,都有不同程度的疗效。尤其重要的是它对大剂量氨甲喋呤、阿霉素等治疗无效的已转移的晚期骨肉瘤亦有一定疗效。它的抗癌作用机制目前还未完全清楚,但已知它能抑制细胞内 DNA 及蛋白质的合
Cisplatin is referred to as cisplatin or cisplatin for short. The full name is cis-Dichlorodiammineplatinum (11), abbreviated as DDP. In 1965, Rosenberg discovered its anti-cancer properties. Many studies have been conducted on this drug, and domestic production has also taken place. It has now proved to be a new broad-spectrum anticancer drug that is effective not only for osteosarcoma and soft tissue sarcoma, but also for head and neck tumors, small cell lung cancer, gynecological malignancies, prostate and bladder cancer, and testicular cancer. There are different degrees of efficacy. Of particular importance is that it has a certain effect on metastatic advanced osteosarcoma that is ineffective for large doses of methotrexate, doxorubicin and other treatments. Its anti-cancer mechanism is not yet fully understood, but it is known to inhibit the combination of intracellular DNA and proteins.