目的　探讨围生期中、重度缺氧缺血性脑损伤对患儿神经系统后遗症的影响。方法　对 12例中、重度缺氧缺血性脑病并有明显神经系统后遗症患儿的临床资料进行回顾性分析。结果　围生期缺氧致新生儿严重抑制状态 ,神经系统症状出现在生后 6h者为 4 2 % ,症状持续 10d以上者为 4 2 % ,6 2 %的患儿惊厥发生在生后 2 4h内 ,80 %患者脑电图严重异常。结论　综合分析围产儿缺氧后临床抑制状况、神经系统症状及脑功能状态 ,对早期预测神经系统后遗症的发生有重要参考价值。 Objective To investigate the effects of mid-term and severe hypoxic-ischemic brain damage on neurological sequelae in children. Methods The clinical data of 12 children with moderate and severe hypoxic-ischemic encephalopathy who had obvious neurological sequelae were retrospectively analyzed. Results Perinatal hypoxia caused severe neonatal inhibition. Neurological symptoms occurred in 42% of patients at 6 hours after birth and 42% after more than 10 days of symptoms. Seizures occurred in 62% of children at 24 hours after birth In 80% of patients with severe EEG abnormalities. Conclusion The comprehensive analysis of the clinical inhibition, neurological symptoms and brain function status after perinatal hypoxia has important reference value for the early prediction of neurological sequelae.