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目的 :探讨人类微小病毒B19与小儿血液病的关系。 方法 :采用酶联免疫吸附 (ELISA)法 ,对 37例血液病患儿的血清标本进行B19 IgM和B19 IgG检测 ,并与对照组进行比较。 结果 :在 37例患儿血清标本中 ,原发性血小板减少性紫癜 (ITP)B19 IgM的阳性检出率为 4 4 4 7% ,再生障碍性贫血 (AA)B19 IgM阳性检出率为4 1 2 % ,与对照组相比 ,差异均有统计学意义 (P <0 .0 5 ) ,急性白血病 (AL)与对照组相比差异无统计学意义 (P >0 .0 5 )。ITP、AA的B19 IgG的阳性检出率与对照组相比差异均无统计学意义 (P >0 .0 5 )。 结论 :人类微小病毒B19感染与ITP、AA有关
Objective: To investigate the relationship between human parvovirus B19 and pediatric hematological diseases. Methods: Serum samples from 37 children with hematological diseases were tested for B19 IgM and B19 IgG by enzyme-linked immunosorbent assay (ELISA) and compared with the control group. Results: The positive rate of B19 IgM in idiopathic thrombocytopenic purpura (ITP) was 44.47% and the positive rate of B19 IgM in aplastic anemia (AA) was 4 in 37 serum samples The difference between the two groups was statistically significant (P <0.05). There was no significant difference between acute leukemia (AL) and control group (P> 0.05). The positive rates of B19 IgG in ITP and AA were not significantly different from those in control group (P> 0.05). Conclusion: Human parvovirus B19 infection is associated with ITP and AA