论文部分内容阅读
IκB激酶-β(IKK-β)是核因子-κB活化所必需的催化亚单位,在受到脂多糖、炎症细胞因子等刺激时呈高表达,通过调节炎症相关基因和抗凋亡基因的表达在慢性肝病的发生发展中起重要作用,应用IKK-β特异抑制剂可能有助于减轻相应的肝脏病变。
IκB kinase-β (IKK-β) is a catalytic subunit necessary for nuclear factor-κB activation, which is highly expressed when stimulated by lipopolysaccharide and inflammatory cytokines. It regulates the expression of inflammation-related genes and anti-apoptotic genes Chronic liver disease plays an important role in the occurrence and development, the application of IKK-β specific inhibitors may help to reduce the corresponding liver lesions.