目的 :探讨糖尿病合并糖尿病视网膜病变患者糖化血红蛋白 (Hb Alc)测定的临床意义 ;方法 :2 39例 型糖尿病患者测定糖化血红蛋白水平及进行眼底检查或眼底荧光造影检查 ,对糖尿病视网膜病变发生率和病变程度与 Hb Alc水平的关系作统计学分析 ;结果 :Hb Alc水平越高 ,视网膜病变的发生率越高 (P<0 .0 5 ) ,Hb Alc≥ 8%时视网膜病变的发生率明显升高 ;Hb Alc水平与视网膜病变的程度呈显著相关性 (r1 =0 .5 99,P<0 .0 1) ;视网膜病变的程度与空腹血糖 (FBG)和病程呈正相关 (r2 =0 .413,r3=0 .431,P<0 .0 1)。结论 :定期监测糖尿病和糖尿病视网膜病变患者的 Hb Alc水平有重要的临床价值。 Objective: To investigate the clinical significance of measuring HbAc in diabetic patients with diabetic retinopathy.Methods: HbAc was measured in 239 patients with type 2 diabetes mellitus and examined by fundus examination or fundus fluorescein angiography. The incidence of diabetic retinopathy and its pathological changes (P <0.05). The higher the Hb Alc level was, the higher the incidence of retinopathy (P <0.05). The incidence of retinopathy was significantly higher when Hb Alc was 8% ; The level of Hb Alc was significantly correlated with the degree of retinopathy (r1 = 0.59, P <0.01); the degree of retinopathy was positively correlated with the duration of FBG (r2 = 0.43, r3 = 0 .431, P <0. 01). Conclusion: Regular monitoring of Hb Alc levels in diabetic and diabetic retinopathy has important clinical value.