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整合素是细胞表面的蛋白分子,是由α和β亚单位组成的异源二聚体,可以介导细胞与细胞、细胞与细胞外基质、细胞与病原体之间的相互作用。对整合素在细菌致病机制中的作用和作为细菌感染治疗潜在靶点两方面的新近研究成果进行了综述。
Integrins are cell-surface protein molecules that are heterodimers of alpha and beta subunits that mediate cell-cell interactions with cells, extracellular matrix, cells and pathogens. This review summarizes the role of integrins in bacterial pathogenesis and as a potential new therapeutic target for bacterial infections.