本文研究了不饱和脂肪酸（鱼油）对脓毒症大鼠枯否氏细胞（KC）膜磷脂的影响,结果表明,脓毒症组大鼠KC膜磷脂酰肌醇（PI）、磷脂酰丝氨酸（PS）、磷脂酰乙醇胺（PE）、磷脂酰胆碱（PC）以及膜上花生四烯酸（AA）含量明显减少,KC培养液中AA代谢产物6-k-PGF_(1a)、TXB_2浓度明显升高。经鱼油治疗后,KC膜结构损伤程度减轻,AA代谢产物减少,提示不饱和脂肪酸有调节KC膜磷脂结构与功能,减少炎性介质产生的作用。 In this paper, the effect of unsaturated fatty acid (fish oil) on the phospholipids of KCs in septic rats was studied. The results showed that the phosphatidylinositol (PI) and phosphatidylserine PS, phosphatidylethanolamine (PE), phosphatidylcholine (PC), and arachidonic acid (AA) content in the membrane were significantly decreased. The concentrations of 6-k-PGF_1a and TXB_2 in the KC culture medium were significantly increased Rise. After fish oil treatment, KC membrane structure damage lessened, AA metabolites decreased, suggesting that unsaturated fatty acids have the regulation of KC membrane phospholipid structure and function, reduce the role of inflammatory mediators.