论文部分内容阅读
目的:观察三氧穴位注射治疗中晚期肺癌的临床疗效及其对免疫功能的影响。方法:将90例TNM分期为Ⅲ~Ⅳ期的肺癌患者随机分为3组(治疗组、对照1组、对照2组)各30例。3组患者均接受基本的西医对症支持治疗,另外,治疗组采用三氧气体穴位注射,对照1组采用生理盐水穴位注射,对照2组不进行穴位注射治疗,穴位注射选穴:肺俞、中府、太渊、膏肓、气海、神门、脾俞、肾俞。观察记录患者治疗前后的症状、体征、KPS评分等临床指标,随访生存期。治疗前后检测白细胞介素-2(IL-2)、肿瘤坏死因子(TNF-α)、表皮生长因子(EGF)、血管内皮生长因子(VEGF)等免疫指标;血常规、肝肾功能、电解质、凝血等血液指标。结果:改善患者症状、提高KPS评分、延长总生存期及无进展生存期治疗组均优于2对照组,差异均有显著性意义(P<0.05);改善免疫功能(IL-2、TNF-α、EGF、VEGF)方面,治疗组4项指标均优于2对照组,差异均有显著性意义(P<0.05)。结论:3氧穴位注射治疗中晚期肺癌有一定疗效。
Objective: To observe the clinical efficacy of Sanxiao acupoint injection in the treatment of advanced lung cancer and its effect on immune function. Methods: Totally 90 lung cancer patients with TNM stage Ⅲ ~ Ⅳ were randomly divided into three groups (treatment group, control group 1 and control group 2). Three groups of patients received basic Western symptomatic supportive treatment. In addition, the treatment group was treated with three oxygen gas injection, the control group 1 with saline injection, the control two groups without acupuncture injection, acupoint injection selected points: Feishu, House, too Yuan, plaster, gas sea, God door, spleen, Shenshu. The patients’ symptoms and signs, KPS score and other clinical indicators before and after treatment were recorded and observed. Survival was followed up. The immune indexes of IL-2, TNF-α, EGF and VEGF were detected before and after treatment. The indexes of blood, liver and kidney, electrolytes, Blood clotting and other indicators. Results: The improvement of symptoms, KPS score, prolong the overall survival and progression-free survival of the treatment group were better than the control group, the difference was significant (P <0.05); improve the immune function (IL-2, TNF- α, EGF, VEGF), the four indexes in the treatment group were better than those in the control group, the difference was significant (P <0.05). Conclusion: 3 Oxygen injection in the treatment of advanced lung cancer have a certain effect.