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目的探讨血清白细胞介素-16(IL-16)在乙型肝炎发病机制中的作用。方法用酶联免疫吸附法(ELISA)测定肝炎患者血清Anti-HAV-IgM、Anti-HCV、Anti-HDV、Anti-HEV-IgM,以排除甲、丙、丁、戊型肝炎的感染;用ELISA法测定乙肝患者血清中IL-16的含量;用酶免疫法(EIA)测定HBsAg、Anti-HBs、HBeAg、Anti-HBe;用连续检测法测定丙氨酸转氨酶(ALT)。结果急性肝炎、重型肝炎血清IL-16水平显著升高(P<0.01)。IL-16水平与ALT水平无明显关系(P>0.05)。结论IL-16参与了乙型肝炎,尤其是急性期的发病过程。检测IL-16水平作为衡量患者肝功能的诊断指标意义不大。
Objective To investigate the role of serum interleukin-16 (IL-16) in the pathogenesis of hepatitis B. Methods Serum Anti-HAV-IgM, Anti-HCV, Anti-HDV and Anti-HEV-IgM were detected by enzyme linked immunosorbent assay (ELISA) Method was used to determine the content of IL-16 in serum of patients with hepatitis B; HBsAg, Anti-HBs, HBeAg and Anti-HBe were determined by enzyme-linked immunosorbent assay (ELISA); ALT was determined by continuous detection. Results Serum levels of IL-16 in acute hepatitis and severe hepatitis were significantly increased (P <0.01). IL-16 levels and ALT levels had no significant relationship (P> 0.05). Conclusion IL-16 is involved in the pathogenesis of hepatitis B, especially in acute stage. Detection of IL-16 levels as a measure of liver function in patients with diagnostic significance is not significant.