论文部分内容阅读
从市售的复方丹参片(糖衣片)可以看出,多有露边现象产生,严重地影响了产品的外观质量。笔者曾对复方丹参糖衣片10多个批号的产品制剂过程中可能引起露边的原因逐一列为考察对象,结果认为露边的主要原因与包粉衣层时的温度有关。同时,经试验得出:温度在20℃(不加热恰好在室温)时,包粉衣可以消去棱角,不露边。笔者认为复方丹参片中的冰片是在压片前加入的,它和颗粒相对独立。由于冰片受热易升华,若包粉衣时的温度高,就使素片中的冰片受热升华到糖衣锅壁上,加大了锅壁的润滑性,导致片子转动失去正常的规律
As can be seen from commercially available compound Danshen tablets (sugar-coated tablets), there are many occurrences of outcrops, which seriously affect the appearance quality of the products. The author has listed the causes of the outbursts in the process of preparation of products containing more than 10 batches of compound salvia miltiorrhiza tablets. The result is that the main cause of the outburst is related to the temperature of the coating powder coating layer. At the same time, the test shows that when the temperature is 20°C (without heating just at room temperature), the coated powder coating can eliminate edges and corners, and does not expose edges. The author believes that the borneol in compound Danshen tablets was added before tableting, and it is relatively independent of the granules. Because the ice flakes are easily sublimated by heat, if the temperature of the coating powder is high, the ice flakes in the plain tablets are sublimated to the wall of the sugar coating pan, which increases the lubricity of the pan wall and causes the normal rotation of the tablets.