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目的观察体温控制对重型颅脑损伤患者血清神经元特异性烯醇化酶(neuron specific enolase,NSE)及Tau蛋白水平的影响及意义。方法 96例重型颅脑损伤患者,随机分为体温控制组35例,亚低温组15例,常规降温组46例。检测各组治疗前及治疗第3、5、7天血清NSE及Tau蛋白水平,并进行比较。结果 3组治疗前NSE、Tau蛋白水平比较差异无统计学意义(P>0.05);治疗第7天,体温控制组、亚低温组血清NSE[(31.82±11.24)、(30.24±9.79)μg/L]、Tau蛋白[(25.67±9.47)、(26.67±10.61)ng/L]均较治疗前[(72.15±15.84)、(72.38±18.91)μg/L,(79.84±18.59)、(77.50±19.69)ng/L]明显下降(P<0.01),但组间比较差异无统计学意义(P>0.05);常规降温组治疗第7天血清NSE[(62.76±13.02)μg/L]、Tau蛋白[(57.50±15.09)ng/L]与治疗前[(75.43±12.83)μg/L、(80.83±17.36)ng/L]比较差异无统计学意义(P>0.05)。结论体温控制可降低重型颅脑损伤患者血清NSE及Tau蛋白水平,起到与亚低温相同的治疗效果。
Objective To observe the effect and significance of body temperature control on serum neuron specific enolase (NSE) and Tau protein in patients with severe craniocerebral injury. Methods A total of 96 patients with severe traumatic brain injury were randomly divided into body temperature control group (n = 35), hypothermia group (n = 15) and routine cooling group (n = 46). The levels of serum NSE and Tau in each group before treatment and on the 3rd, 5th and 7th day of treatment were detected and compared. Results The levels of NSE and Tau in the three groups before treatment were not significantly different (P> 0.05). On the seventh day after treatment, NSE in the body temperature control group and the mild hypothermia group [(31.82 ± 11.24), (30.24 ± 9.79) μg / L and Tau protein in the control group were significantly higher than those before treatment [(72.15 ± 15.84), (72.38 ± 18.91) μg / L, (79.84 ± 18.59), (77.50 ± (62.76 ± 13.02) μg / L] on the 7th day after treatment in the conventional cooling group, while Tau was significantly lower on the 7th day after treatment in the conventional cooling group (P <0.01), but the difference was not statistically significant (57.50 ± 15.09) ng / L compared with those before treatment [(75.43 ± 12.83) μg / L, (80.83 ± 17.36) ng / L], but there was no significant difference between the two groups (P> 0.05). Conclusion Body temperature control can reduce serum NSE and Tau protein levels in patients with severe traumatic brain injury and play the same therapeutic effect as mild hypothermia.