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研究血浆内皮素－1（ET－1）的浓度与小儿先天性室间隔缺损伴肺动脉高压的关系。42例小儿室间隔缺损心内直视修补术病例，围术期采用放射免疫法测定血浆EF－1。结果：血浆ET－1明显高于正常，而主动脉血样ET－1略高于肺动脉血样中ET－1。肺动脉高压组术前ET－1明显高于肺动脉压力正常组（P＜0．01）。逐步回归发现ET－1与肺循环流量和脉动脉压力呈线性相关。动态观察发现体外循环结束时ET－1较转流前升高，术后24h则降至低于术前水平。结论：结果表明在小儿室间隔缺损中ET－1与肺动脉高压的发生密切相关。
To investigate the relationship between plasma endothelin-1 (ET-1) concentration and congenital ventricular septal defect in children with pulmonary hypertension. 42 cases of ventricular septal defect open heart surgery cases, perioperative radioimmunoassay of plasma EF-1. Results: Plasma ET-1 was significantly higher than normal, while ET-1 in aortic blood was slightly higher than ET-1 in pulmonary arterial blood. Preoperative ET-1 in pulmonary hypertension group was significantly higher than that in normal pulmonary hypertension group (P <0.01). A stepwise regression found that ET-1 was linearly correlated with pulmonary circulation flow and pulse pressure. Dynamic observation found that ET-1 increased at the end of cardiopulmonary bypass compared with that before commutation, and then decreased to below the preoperative level at 24h after CPB. CONCLUSIONS: The results show that ET-1 is associated with pulmonary hypertension in children with ventricular septal defect.