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目的观察补充微量营养素是否改善女性2型糖尿病患者的细胞免疫(T细胞免疫)功能和降低一般感染发生率。方法按随机双盲安慰剂对照的研究方法,分别给予122例女性2型糖尿病患者微量营养素制剂和安慰剂,连续服用6个月。研究开始前和6个月时进行人体测量、血液生化和细胞免疫检查。研究前1个月及研究期间每月进行随访,每2周填写饮食和运动记录表、感染登记表。结果研究结束后10人退出研究,脱落率8.2%,获得有效数据者112例。研究开始前两组基本情况及各项指标间差异均无统计学意义,研究结束后干预组CD4+、CD8+、CD4+/CD8+比例变化值均显著高于对照组;干预组在研究期间发热率、每次发热时体温、发热时持续时间、感冒发生率、皮肤脓肿与破溃发生率均低于对照组。结论适量补充微量营养素可改善女性2型糖尿病患者T细胞功能、降低一般感染的发生率。
Objective To investigate whether supplementation with micronutrients improves cellular immunity (T cell immunity) in women with type 2 diabetes and reduces the incidence of general infection. Methods According to a randomized, double-blind, placebo-controlled study, 122 women with type 2 diabetes were given micronutrient and placebo, respectively, for 6 months. Anthropometric, blood biochemical, and cellular immunological tests were performed prior to and six months into the study. One month prior to the study and a monthly follow-up during the study period. Fill in the diet and exercise schedules every two weeks and register the infection. Results After the study ended 10 people withdrew from the study, shedding rate of 8.2%, access to valid data in 112 cases. Before the start of the study, there was no significant difference between the two groups in basic conditions and in all indexes. After the study, the changes of CD4 +, CD8 + and CD4 + / CD8 + ratio in the intervention group were significantly higher than those in the control group. In the intervention group, Sub-fever body temperature, duration of fever, the incidence of colds, skin abscess and ulceration rates were lower than the control group. Conclusion Appropriate amount of micronutrient supplementation can improve T cell function in women with type 2 diabetes and reduce the incidence of general infection.