目的探讨内皮素在脑梗死发病中的作用及其临床意义。方法运用放射免疫方法测定脑梗死患者血浆及脑脊液中内皮素的含量 ,应用SPSS软件包进行统计学分析。结果患者急性期血浆、脑脊液内皮素水平均显著高于对照组。伴高血压的患者急性期血浆内皮素较不伴高血压的患者显著升高 ,而脑脊液水平虽高 ,但没有显著性差异。患者急性期血浆内皮素水平与血脂、纤维蛋白原及血流动力学均无显著相关关系。结论内皮素在脑梗死发病中可能有其独特的作用机制 Objective To investigate the role of endothelin in the pathogenesis of cerebral infarction and its clinical significance. Methods The levels of endothelin in plasma and cerebrospinal fluid (CSF) of patients with cerebral infarction were measured by radioimmunoassay. SPSS software package was used for statistical analysis. Results The levels of plasma and cerebrospinal fluid endothelin in acute stage were significantly higher than those in control group. In patients with hypertension, the plasma endothelin in patients with acute phase was significantly higher than those without hypertension, while the level of cerebrospinal fluid was high, but there was no significant difference. There was no significant correlation between plasma endothelin level and serum lipids, fibrinogen and hemodynamics in patients with acute phase. Conclusion Endothelin may have its unique mechanism of action in the pathogenesis of cerebral infarction