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目的：了解雪旺细胞（ＳＣ）促进脊髓受损轴索再生作用。方法：将Ｗｉｓｔａｒ大鼠２０只随机分为两组，各１０只，实验组将自成鼠坐骨神经培养获取的雪旺细胞悬液（ＳＣＳ）采用显微注射植入成鼠正常胸段（Ｔ７）脊髓，对照组以相同量的Ｄｕｌｂｅｃｃｏ改良细胞培养液（ＤＭＥＭ）植入。移植术后２周、６周通过组织学及免疫组织化学检查，观察移植物的存活及促进轴索再生能力。结果：实验组宿主中ＳＣ形态正常，束状排列，轴索可长入移植物中。束状排列的ＳＣ间有髓鞘碱性蛋白（ＭＢＰ）阳性纤维存在，相伴随的ＳＣ胞质亦呈ＭＢＰ阳性。对照组无再生轴索长入。结论：ＳＣ植入成鼠正常脊髓后，与宿主融合好，可存活，促进宿主再生轴索越过宿主－移植物交界面长入移植物，并形成髓鞘。
Objective: To investigate whether Schwann cells (SCs) promote axonal regeneration after spinal cord injury. Methods: Twenty Wistar rats were randomly divided into two groups (n = 10). The experimental group received Schwann cell suspension (SCS) obtained from the sciatic nerve of adult rats and injected into the normal rat thoracic segment (T7) Spinal cord, control group were implanted with the same amount of Dulbecco’s modified cell culture medium (DMEM). At 2 weeks and 6 weeks after transplantation, histological and immunohistochemical examinations were performed to observe the graft survival and axonal regeneration. Results: The morphology of SC in the experimental group was normal, and the axons could grow into the graft. The bundle-like intermedial myelin basic protein (MBP) -positive fibers existed, and the accompanying SC cytoplasm also showed MBP positive. The control group without regenerative axillary growth. CONCLUSIONS: After SC is implanted into the normal spinal cord of rats, it fusibly integrates with the host and survives. It promotes the regeneration of the host axon and transplants through the host-graft interface and forms myelin sheath.