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目的探讨奥美拉唑联合奥曲肽治疗肝硬化上消化道出血的临床疗效与安全性。方法 102例肝硬化上消化道出血患者作为此次研究对象,随机将患者分成对照组与治疗组,每组51例。对照组单用奥美拉唑治疗,治疗组应用奥美拉唑联合奥曲肽治疗,比较两组患者的临床疗效与安全性。结果治疗组患者的平均止血时间、输血量以及住院时间均显著少于对照组(P<0.05);治疗组治疗总有效率为94.12%,不良反应发生率为5.88%,均优于对照组的68.63%、33.33%,差异具有统计学意义(P<0.05)。结论肝硬化上消化道出血应用奥美拉唑联合奥曲肽治疗能够获得显著临床疗效,可显著减少患者出血量,安全性高,值得临床推广。
Objective To investigate the clinical efficacy and safety of omeprazole combined with octreotide in the treatment of upper gastrointestinal bleeding in cirrhosis. Methods A total of 102 patients with cirrhosis and upper gastrointestinal bleeding were randomly divided into control group and treatment group with 51 cases in each group. The control group was treated with omeprazole alone. The treatment group was treated with omeprazole and octreotide. The clinical efficacy and safety of the two groups were compared. Results The mean hemostasis time, blood transfusion and hospital stay in the treatment group were significantly less than those in the control group (P <0.05). The total effective rate was 94.12% in the treatment group and 5.88% in the adverse reaction group, which were better than those in the control group 68.63%, 33.33%, the difference was statistically significant (P <0.05). Conclusion The application of omeprazole combined with octreotide in patients with cirrhosis and upper gastrointestinal bleeding can achieve significant clinical curative effect, which can significantly reduce the amount of bleeding in patients with high safety and worthy of clinical promotion.