论文部分内容阅读
目的制备盐酸洛美沙星淀粉微球,并对其体外释药模式进行研究。方法以盐酸洛美沙星为模型药物,采用吸附载药法和包埋载药法制备了载药淀粉微球,通过测定微球载药量、包封率和在不同的释放介质中的体外释放情况,对上述2种方法制备的载药微球进行质量评价。结果吸附法制备的载药微球的平均载药量为14.54μg·mg-1,药物包封率为39.72%;而包埋载药法制备的淀粉微球的平均载药量为19.32μg·mg-1,药物包封率为48.95%。体外释药特性研究表明它们具有缓释特性,其中包埋载药法制备的淀粉微球比吸附载药法制备的淀粉微球有更好的缓释能力,在不同的释放介质中释药曲线也有所不同,在模拟胃液中累计释药量只能得到70%;而在模拟肠液中累计释药量能达到80%以上。结论吸附载药法和包埋载药法制备的载药淀粉微球都具有缓释作用,但后者体外释药具有更明显的缓释效果。
Objective To prepare Lomefloxacin Hydrochloride-containing microspheres and study its in vitro release patterns. Methods Lomefloxacin hydrochloride was used as a model drug. The drug-loaded starch microspheres were prepared by adsorption method and drug-loading method. The drug loading, entrapment efficiency and in vitro release in different release media The quality of drug-loaded microspheres prepared by the above two methods was evaluated. Results The average drug loading of microspheres prepared by adsorption method was 14.54 μg · mg-1 and the drug entrapment efficiency was 39.72%. The average drug loading of starch microspheres prepared by drug-loading method was 19.32 μg · mg-1, drug entrapment efficiency of 48.95%. In vitro release characteristics of the study showed that they have a sustained-release properties, which embedding drug-loaded starch microspheres prepared by adsorption drug-loaded starch microspheres better release capacity in different release medium drug release curve Is also different, in the simulated gastric fluid cumulative release amount can only get 70%; and in the simulated intestinal fluid cumulative release amount can reach more than 80%. Conclusion Both drug-loading and drug-loading starch microspheres have sustained release, but the drug release in vitro has a more obvious sustained-release effect.