死亡分子与死亡分子受体相互作用引发的细胞凋亡在保持自身平稳发挥着无法代替的重要作用。目前ＦａｓＬ、ＴＮＦ和ＴＲＡ１ 三个死亡分子及Ｆａｓ、ＴＮＦＲ、ＤＲ３／ＷＳ１１ 和ＣＡＲ１ 四个死亡分子受体已被确定。本文就ＦａｓＬ和ＴＮＦ两个死亡分子在与其受体、Ｆａｓ 下调免疫反应、效应分子和免疫特赦的研究现状予以综述。 Apoptosis triggered by the interaction between death and death receptors plays an irreplaceable role in maintaining their own stability. At present, three death molecules of FasL, TNF and TRA1 and four death receptors of Fas, TNFR, DR3 / WS1-1 and CAR1 have been identified. In this paper, we reviewed the current status of FasL and TNF death in their receptors, Fas down-regulation of immune responses, effector molecules and immune amnesty.