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目的探讨补阳还五汤煎剂联合西药治疗气虚血瘀证急性脑梗塞的疗效。方法将我院收治的120例气虚血瘀证急性脑梗塞患者根据随机数字表法分为对照组与观察组各60例,对照组接受西医常规治疗,观察组则在西医常规治疗基础上再加用补阳还五汤治疗,对比分析两组患者的疗效。结果 (1)观察组疗效总有效率(95.00%)显著高于对照组(83.33%),有显著性差异(P<0.05)。(2)治疗前组间比较显示:两组患者血浆纤维蛋白原(Fbg)、红细胞压积(HCT)、全血低切粘度、血浆粘度相比差异无统计学意义(P>0.05);组内治疗前后比较显示:观察组与对照组患者血浆Fbg、HCT、全血低切粘度、血浆粘度治疗后均显著下降(P<0.05);治疗后组间比较显示:观察组血浆Fbg、HCT、全血低切粘度、血浆粘度显著低于对照组(P<0.05)。(3)治疗前组间比较显示:两组患者美国国立卫生院神经功能缺损评分(NIHSS)、FuglMeyer运动功能评定量表(FMA)评分、日常生活能力量表(ADL)评分相比差异无统计学意义(P>0.05);组内治疗前后比较显示:观察组与对照组患者NIHSS均显著下降(P<0.05),FMA评分、ADL评分均显著升高(P<0.05);治疗后组间比较显示:观察组NIHSS显著低于对照组(P<0.05),FMA评分、ADL评分显著高于对照组(P<0.05)。结论补阳还五汤煎剂联合西药可以改善气虚血瘀证急性脑梗塞患者的血液流变学指标,疗效显著,值得临床推广应用。
Objective To investigate the curative effect of Buyang Huanwu Decoction combined with western medicine on acute cerebral infarction with Qi-deficiency and Blood-stasis syndrome. Methods A total of 120 patients with acute cerebral infarction with Qi-deficiency and Blood-Stasis syndrome admitted to our hospital were divided into control group and observation group according to the random number table method, 60 patients in each group. The control group received routine treatment of western medicine, and the observation group was added on the basis of western medicine routine treatment With Bu Yang Huanwu Tang treatment, comparative analysis of the efficacy of two groups of patients. Results (1) The total effective rate of the observation group (95.00%) was significantly higher than that of the control group (83.33%), with significant difference (P <0.05). (2) The comparison of pre-treatment group showed that there was no significant difference in plasma Fbg, HCT, low-shear viscosity and plasma viscosity between the two groups (P> 0.05) After treatment, the levels of plasma Fbg, HCT, whole blood low shear viscosity and plasma viscosity decreased significantly after treatment (P <0.05). After treatment, the levels of Fbg, HCT, Whole blood low shear viscosity, plasma viscosity was significantly lower than the control group (P <0.05). (3) Before treatment, the comparison between the two groups showed no difference in NIHSS, FgG, ADL score between the two groups (P <0.05). The comparison of before and after treatment showed that NIHSS in observation group and control group were significantly decreased (P <0.05), FMA score and ADL score were significantly increased (P <0.05) The comparison showed that the NIHSS in observation group was significantly lower than that in control group (P <0.05), FMA score and ADL score were significantly higher than those in control group (P <0.05). Conclusion Decoction of combination of Huanyu Huanwu Decoction with western medicine can improve the hemorheology indexes of patients with acute cerebral infarction with Qi-deficiency and blood-stasis syndrome, and the curative effect is remarkable. It is worthy of clinical application.