甲硝羟乙唑衍生物(CM)对小鼠经腹腔或静脉注射后,有明显的神经毒反应,症状随剂量的增加而加重。三批CM经腹注测得LD_(50)平均值为5034mg/kg,经统计分析其致死效应完全一致。三批CM经静注测得LD_(50)平均值为3186mg/kg,经统计分析致死性质相同,但因个体差异对静注反应敏感,故8638和8646两批间有显著性差别。 Metronidazole derivatives (CM) after intraperitoneal or intravenous injection of mice, there is a significant neurotoxic reaction, the symptoms increased with increasing doses. Three batches of CM by abdominal injection measured LD_ (50) average of 5034mg / kg, the statistical analysis of its lethal effect is exactly the same. Three groups of CM measured by intravenous injection of LD_ (50) average of 3186mg / kg, the same statistical analysis of the same lethality, but due to individual differences in sensitivity to intravenous reactions, so 8638 and 8646 between the two batches were significantly different.