采用免疫组化方法，取胃窦部粘膜上皮，对２９例慢性胃炎和腺癌组织肿瘤抑制基因Ｍａｓｐｉｎ的表达变化进行比较研究。结果：Ｍａｓｐｉｎ蛋白在慢性胃炎中的表达率为５３％（８／１５），在胃癌中的表达率为２１％（３／１４），两者差异有显著性（Ｐ＜０．０５），且Ｍａｓｐｉｎ蛋白在慢性胃炎和腺癌病变中的免疫反应类型不同，前者免疫反应部位以胞浆为主，后者主要位于胞核。提示：Ｍａｓｐｉｎ的表达是胃癌癌变早期阶段的一种重要分子学改变。 Using immunohistochemical method, gastric mucosal epithelium was taken, and the expression changes of tumor suppressor gene Maspin in 29 cases of chronic gastritis and adenocarcinoma were compared. Results: The expression rate of Maspin protein in chronic gastritis was 53% (8/15). The expression rate of Maspin protein in gastric cancer was 21% (3/14). There was a significant difference between them (P<0.05). Maspin protein has different types of immune responses in chronic gastritis and adenocarcinoma lesions. The immunoreactive site of the former is mainly cytoplasm and the latter is mainly located in the nucleus. Tip: The expression of Maspin is an important molecular change in the early stages of gastric carcinogenesis.