论文部分内容阅读
金石散慢性毒性试验取豚鼠和大鼠进行。１．取５０只豚鼠，随机分为５组，即高、中、低剂量组及ＵＤＣＡ和生理盐水两组为对照组。每只豚鼠每日经口灌服相应药物，１月后采血作肝、肾功能测定。２．取８０只大鼠，随机分为４组，即高、中、低剂量及生理盐水组，每日灌服相应药物，连续９月。其中半数动物在６个月时采血作肝、肾功能试验。９月后处死，作各主要脏器功能及组织学检查，包括体重、血、尿常规、血生化指标如血糖、血清蛋白、胆固醇、谷丙及谷草转氨酶、碱性磷酸酶、尿素氮和肌酐等，以及心、脑、肾、肝、肺、甲状腺、肾上腺和脾等脏器的重量指数、组织切片学。结果显示即使每日连续给药达９月之久，对机体也无明显的副作用或毒性作用。
Jinshisan chronic toxicity test was performed on guinea pigs and rats. 1. Fifty guinea pigs were randomly divided into five groups, namely, high, medium, low dose group and UDCA and saline two groups as the control group. Each guinea pig was orally administrated with the corresponding drug daily, and blood was collected after 1 month for liver and kidney function tests. 2. 80 rats were randomly divided into 4 groups: high, medium, low dose, and normal saline groups. The corresponding drugs were given daily for 9 months. Half of the animals collected blood for liver and kidney function tests at 6 months. After being sacrificed in September, major organ functions and histological examinations were performed, including weight, blood, urine routine, blood biochemical indicators such as blood glucose, serum albumin, cholesterol, gluten and aspartate aminotransferase, alkaline phosphatase, urea nitrogen, and creatinine. Etc., and the weight index and histology of organs such as heart, brain, kidney, liver, lung, thyroid gland, adrenal gland and spleen. The results showed that there was no obvious side effect or toxic effect on the body even if continuous administration was continued for 9 months per day.