论文部分内容阅读
山莨菪碱(anisodamine)为中国首先自特产茄科植物唐古特山莨菪(Scopolia tangutica Maxim.)中提取得到的一种生物碱。自七十年代以来,我国科学工作者从化学,药理、临床等多方面对山莨菪碱进行了大量的研究,其化学结构与阿托品相似,除阻滞M—胆碱受体外,还有改善微循环、抗休克和钙拮抗作用等,山茛菪碱成为我国医药研究中较为活跃的研究对象。目前临床上应用的山莨菪碱类药物绝大多数是人工合成品——消旋山莨菪碱(654-2)的氢溴酸盐或盐酸盐。中国药典1990版收载的质控方法是:原料药采用高氯酸滴定,片剂及针剂采用溴甲酚绿酸性染料比色。山莨菪碱片剂的溶出度测定,现有的方法难于胜任,亟需发展一种灵敏度更高的含量测定方法。用HPLC法测定山莨菪碱及其制剂的研究,目前国内外还未见报道。
Anisodamine is an alkaloid first extracted from Scopolia tangutica Maxim., A Chinese solanaceae family. Since the 1970s, scientists in our country have done a great deal of research on anisodamine in chemical, pharmacological and clinical aspects. Its chemical structure is similar to that of atropine. In addition to blocking M-choline receptors, there is also improvement Microcirculation, anti-shock and calcium antagonism, etc. Anisodamine has become a more active research object in Chinese medical research. At present, the vast majority of anisodamine used clinically is the hydrobromide or hydrochloride of synthetic anisodamine (654-2). Chinese Pharmacopoeia 1990 edition contained quality control methods are: raw materials used perchloric acid titration, tablets and injections using bromocresol green acid dye colorimetric. Determination of the dissolution of anisodamine tablets, the existing method is difficult to competent, the urgent need to develop a more sensitive determination of content. Study on the determination of anisodamine and its preparation by HPLC has not been reported at home and abroad.